Scientific researches

How does it works ?

FOCUS

Lion's Mane (Hericium erinaceus): Focus on Cognitive and Nerve Health

Modern scientific research has investigated the

neurobiological

mechanisms and potential

cognitive benefits

of Lion's Mane mushroom, which has a history of use in traditional medicine.

Primary Bioactive Compounds and Mechanism: The neurotrophic properties are primarily attributed to specific terpenoids: hericenones (from the fruiting body) and erinacines (from the mycelium). Notably, preclinical research indicates that erinacines, such as erinacine A, can cross the blood-brain barrier and stimulate the synthesis of

Nerve Growth Factor (NGF)

and

Brain-Derived Neurotrophic Factor (BDNF)

which are crucial for neuronal growth, maintenance, and survival. This mechanism underpins much of the research interest in neuroprotection.

Supporting Mechanisms and Broader Bioactivity

Antioxidant & Anti-inflammatory

Its polysaccharides and phenolic compounds combat oxidative stress and neuroinflammation, which are underlying factors in cognitive decline.

Antimicrobial

Exhibits activity against various pathogens, contributing to its role in supporting overall systemic health.

Human clinical results

Study on healthy young adults found a single 1.8g dose improved speed on a cognitive task 60 minutes post-dose, with a trend toward reduced stress after 28 days. Other trials note improvements in cognitive test scores in older adults with mild impairment after 12-16 weeks of supplementation (3g/day). A 49-week study in mild Alzheimer's patients reported improved daily living.

Scientific Researches

CALM

Reishi Mushroom (Ganoderma lucidum): Systemic Immunomodulation

Reishi, used for millennia in traditional medicine, is now recognized by modern science as apotent

adaptogen

and

immunomodulator

primarily due to two classes of compounds.

Core Mechanism: Polysaccharide & Triterpenoid ActionReishi's effects are chiefly attributed to

polysaccharides (especially B-glucans)

and

triterpenoids

These compounds work through sophisticated immunological pathways.

Immune Cell Activation

The polysaccharides bind to receptors (like dectin-1, TLRs) on immune cells (macrophages, natural killer cells, T-cells), enhancing their surveillance, phagocytosis, and cytokine production.

Signaling Pathway Regulation

Triterpenoids modulate key inflammatory pathways (NF-KB, MAPK), helping to regulate the body's immune and inflammatory responses

Gut-Brain Axis Influence

Research indicates Reishi can modulate gut microbiota, which in turn impacts systemic immunity and inflammation, connecting it to the gut-liver-brain axis.

Clinical Research and Global Use

Clinical evidence supports its role in symptom management and immune supportSurvey of over 1,300 patients in China found reported significant improvement in treatment-re-lated symptoms like nausea, fatigue, and poor appetite after using Reishi. Randomized controlled trial on healthy adults found that 84 days of supplementation with a purified Reishi B-glu-can significantly enhanced key immune parameters, including T-lymphocyte populations and natural killer cell activity. Its global application is vast, used in dietary supplements, functional foods, and even as a prescription drug in some Asian countries.

Scientific Researches